What is the icd 10 code for myelodysplastic syndrome

Name

Myelodysplastic syndrome with excess blasts

ICD-O-2 Morphology

Effective 1992 - 2000

ICD-O-3 Morphology

Effective 2001 and later

Reportable

for cases diagnosed 2001 and later

Primary site must be bone marrow (C421)

Help me code for diagnosis year :

Abstractor Notes

Diagnostic Confirmation

This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.

Alternate Names

MDS-EB

MDS-EB-1

MDS-EB-2

Myelodysplastic syndrome with excess blasts 1

Myelodysplastic syndrome with excess blasts 2

RAEB, NOS

RAEB I

RAEB II

RAEB-T

Refractory anemia with excess blasts, NOS

Refractory anemia with excess blasts in transformation

Definition

RAEB-1 (Type 1) and RAEB-2 (Type 2) are defined based on the number of blasts:
1. RAEB-1: 5-9% blasts in bone marrow, < 5% blasts in blood
2. RAEB-2: 10-19% blasts in bone marrow
(note if 5-19% blasts in blood and < 10% blasts in marrow, should be RAEB-2 OR RAEB with Auer rods). aka RAEB-T (RAEB in transformation which has ICD-O-3 code of 9984/3)

Definitive Diagnostic Methods

Bone marrow biopsy

Genetic testing

Immunophenotyping

Genetics Data

-5

-7

8

del (5q)

del (7q)

del (20q)

Immunophenotyping

Treatments

Chemotherapy

Hematologic Transplant and/or Endocrine Procedures

Immunotherapy

Transformations to

Transformations from

None

Same Primaries

Corresponding ICD-9 Codes

238.73 High grade myelodysplastic syndrome

238.72 Low grade myelodysplastic syndrome

Corresponding ICD-10 Codes

D46.2 Refractory anemia with excess of blasts

Corresponding ICD-10-CM Codes (U.S. only)

D46.20 Refractory anemia with excess of blasts, unspecified (effective October 01, 2015)

D46.21 Refractory anemia with excess of blasts 1 (effective October 01, 2015)

D46.22 Refractory anemia with excess of blasts 2 (effective October 01, 2015)

Signs and Symptoms

Anemia

Easy bruising or bleeding

Neutropenia

Petechiae (flat, pinpoint spots under the skin caused by bleeding)

Shortness of breath

Skin paler than usual

Thrombocytopenia

Weakness or feeling tired

Diagnostic Exams

FISH (flourescence in situ hybridzation)

Flow cytometry

Immunocytochemistry

Immunophenotyping

Peripheral blood smear

Progression and Transformation

~25% of RAEB-1 and 33% of RAEB-2 transform to AML

Epidemiology and Mortality

Age: > 50 years of age

Incidence: ~40% of all MDS

Sex: no male or female predominance

Survival: ~16 months for RAEB-1 and ~3-12 months for RAEB-2

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Myelodysplastic syndromes
Pages: 113-114

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: //www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

National Cancer Institute
Section: General Information About Myelodysplastic Syndromes
Pages: //www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq

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